· Even in extendedrelease versions, OxyContin can lead to the development of physical dependence, meaning that when someone stops taking the drug, they go through withdrawal. OxyContin 10 mg High. An OxyContin 10 mg high is likely less powerful than using higher doses of the drug, and the extendedrelease form of the drug also affects the high. Extendedrelease opioids are intended to not .